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Pga. lidelsens heterogenitet varierer effekten av medikamentell behandling fra pasient til pasient. Den kliniske erfaringen er at kombinasjon av medikamenter med ulike virkningsmekanismer er gunstig hos de fleste, Adult men det foreligger ikke randomiserte, kontrollerte studier på dette.Adjuvanser brukes ikke som monoterapi ved kroniske smerter. D
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